NAD+ 500mg

NAD+ (Nicotinamide Adenine Dinucleotide) is one of the most critical molecules in biology — a coenzyme present in every living cell that serves as the primary electron carrier in cellular energy metabolism. NAD+ is essential for converting nutrients into ATP (cellular energy) and serves as a required cofactor for over 500 enzymatic reactions.

The Aging-NAD+ Connection

NAD+ levels decline dramatically with age. By age 50, most individuals have approximately 50% of the NAD+ levels they had at age 20. By age 80, this drops to as low as 10–15% of youthful levels. This decline is now recognized as a central mechanism of the aging process — not just a consequence.

As NAD+ declines: - Mitochondrial function deteriorates (less energy production) - Sirtuin activity drops (impaired DNA repair and gene regulation) - PARP enzymes (DNA damage response) become less efficient - Cellular senescence accelerates

Sirtuin Activation — The Longevity Pathway

NAD+ is the required substrate for sirtuin enzymes (SIRT1–SIRT7) — the so-called "longevity proteins" that regulate DNA repair, inflammation, mitochondrial biogenesis, and metabolic health. Without adequate NAD+, sirtuins cannot function. Restoring NAD+ essentially reactivates the body's cellular maintenance programs.

Research Evidence

Human clinical trials with NAD+ precursors and direct NAD+ supplementation have documented improvements in: - Mitochondrial function and energy production - Cognitive performance and neurological health - Physical endurance and muscle function - Metabolic health markers (insulin sensitivity, lipid profiles)