GHK-Cu

GHK-Cu (Glycyl-L-Histidyl-L-Lysine : Copper) is a naturally occurring human plasma tripeptide that has emerged as one of the most scientifically compelling anti-aging compounds. It naturally declines with age — plasma concentrations drop from approximately 200ng/mL at age 20 to 80ng/mL at age 60 — and this decline correlates with many hallmarks of aging.

The Gene Expression Reset

Perhaps the most remarkable property of GHK-Cu is its ability to modulate gene expression at a profound level. Research by Dr. Loren Pickart demonstrated that GHK-Cu resets approximately 30% of age-related gene dysregulation — effectively reversing aging-associated changes in the activity of over 4,000 genes.

This includes upregulating genes involved in collagen synthesis, anti-oxidant defense, DNA repair, and nerve growth — while downregulating genes associated with inflammation, cancer proliferation, and oxidative stress.

Skin and Collagen Effects

GHK-Cu is the most evidence-backed peptide for skin rejuvenation. It: - Increases collagen synthesis by up to 70% in fibroblast studies - Stimulates elastin production and proteoglycans for skin plumpness - Activates tissue remodeling enzymes (matrix metalloproteinases) - Improves skin density, firmness, and reduces fine line depth

Hair Restoration

GHK-Cu stimulates hair follicle stem cells and enlarges hair follicle size, making it one of the most studied peptides for hair loss applications. Applied topically to the scalp, it promotes follicle recovery and hair regrowth comparable to minoxidil in peer-reviewed studies.